
Oral Supplements and Medications for Melasma in Malaysia – What Really Works?
Introduction: Beyond Creams and Lasers – Can Oral Treatments Help Melasma?
Melasma is one of the most stubborn pigmentation problems in Malaysia, often made worse by our tropical sun exposure. While topical creams and advanced lasers such as Pico Laser and Sylfirm X are widely used, many patients are now turning to oral supplements and medications to enhance treatment results.
At NextMed Clinic, we combine oral treatments with in-clinic therapies to help our patients achieve faster, safer, and longer-lasting improvements. In this article, we explore the best oral supplements and medications for melasma in Malaysia, their benefits, and how they fit into a comprehensive treatment plan.
Table of Contents
Why Oral Treatments for Melasma?



Traditional creams, like hydroquinone, are no longer the gold standard due to risks such as:
Exogenous ochronosis (rebound pigmentation & skin darkening)
Skin irritation and thinning
Potential long-term safety concerns
Oral therapies offer a systemic approach by targeting pigmentation from within. They can:
Reduce oxidative stress that triggers melanin production
Regulate tyrosinase activity (the enzyme responsible for pigmentation)
Improve overall skin clarity and brightness
Complement lasers, mesotherapy, and depigmentation procedures
Top Oral Treatments for Melasma in Malaysia
1. NanoMD® Bright
A powerful nutraceutical supplement designed for skin whitening and anti-aging.
Key Ingredients: Nano polypodium leucotomos, Vitamin C, antioxidants
Benefits: Reduces UV-induced pigmentation, protects skin cells, and enhances laser results.
Best For: Patients seeking a non-drug, safe daily supplement for melasma prevention and maintenance.
2. Oxithion (L-Glutathione + Vitamin C Complex)
A potent oral antioxidant supplement widely used in Malaysia for pigmentation and skin health.
Key Benefits:
Neutralizes free radicals that worsen melasma
Promotes a brighter, more even skin tone
Supports liver detoxification, indirectly benefiting skin clarity
Note: Works best when combined with sun protection and in-clinic procedures.
3. Oral Tranexamic Acid (TXA)
One of the most studied oral treatments for melasma.
Mechanism: Blocks plasmin activity, reducing UV-induced melanocyte activation.
Results: Clinical studies show visible lightening of melasma within 8–12 weeks.
Considerations: Requires doctor supervision, as it carries rare risks like blood clotting.
Best Candidates: Patients with moderate to severe melasma unresponsive to creams alone.
How We Use Oral Treatments at NextMed Clinic
At NextMed Clinic Malaysia, we create personalized treatment plans by combining oral therapies with other evidence-based treatments:
Lasers: Pico Laser & Sylfirm X for pigment breakdown and collagen remodeling
Mesotherapy: Dermal Sign E+ depigmentation cocktail for direct skin lightening
Topical Regimens: Cyntra & Heliocare sun protection systems
Lifestyle Advice: UV avoidance, sunscreen use, and dietary support
By combining oral, topical, and in-clinic solutions, patients achieve a holistic melasma management strategy with long-lasting results.
Who Should Consider Oral Supplements for Melasma?

Oral therapies may be ideal for:
✔ Patients with stubborn melasma not improving with creams alone
✔ Individuals seeking a safe, long-term maintenance solution
✔ Patients undergoing laser or mesotherapy treatments who want faster results
✔ Busy professionals looking for a simple daily routine to support their skin

Safety and Precautions
Always consult a doctor before starting oral treatments, especially tranexamic acid.
Pregnant or breastfeeding women should avoid TXA and consult their doctor for alternatives.
Supplements like NanoMD and Oxithione are generally safe, but professional guidance ensures optimal results.

Conclusion: A Complete Inside-Out Approach to Melasma Treatment in Malaysia
Melasma is complex and often requires more than just creams or lasers. Oral supplements and medications such as NanoMD, Oxithione, and oral tranexamic acid offer an effective inside-out solution, especially when combined with advanced in-clinic treatments.
At NextMed Clinic Malaysia, we specialize in comprehensive melasma treatment plans, tailored to your skin type and pigmentation severity.
👉 Learn more about our full range of melasma solutions here:
Best Melasma Treatment in Malaysia – Options That Work in 2025

At Next Med Clinic, we understand that customers need gentle yet effective treatments to prevent long-term damage to their skin. Here’s why we are the best clinic for pigmentation melasma treatment in Malaysia:
1. Expert Doctors Specializing in Melasma Treatments
Our team consists of highly trained doctors and dermatologists with expertise in acne scar removal. Each treatment is tailored to suit different skin types and conditions.
2. Advanced and Safe Technologies
We use FDA-approved laser treatments, microneedling, and PRP therapy, ensuring safe and effective pigmentation removal with minimal discomfort.
3. Customized Treatment Plans for All customers
Every teen’s skin is different. Our specialists provide personalized consultations to create the best treatment plan based on the severity of pigmentation.
4. Affordable and Transparent Pricing
We offer affordable acne scar treatments with no hidden charges, making it accessible for teenagers and their parents.
5. Minimal Downtime & Fast Recovery
Our treatments are designed to minimize downtime, so customers can quickly return to work and daily activities.
6. Positive Reviews from Satisfied Patients
Many Malaysian have successfully treated their pigmentations at Next Med Clinic. Our results speak for themselves!

1. Book a Consultation at Next Med Clinic
The first step is to schedule a consultation with our experts. We will assess your skin and recommend the most suitable treatment.
2. Follow a Personalized Pigmentation Treatment Plan
Based on your skin type and pigmentation, we will create a customized treatment plan for the best results.
3. Maintain a Good Skincare Routine
After treatment, proper skincare is essential to prevent new acne breakouts and scars. We provide professional guidance on maintaining clear skin.
Book Appointment Today!
📞 Call us today at Hotline Malaysia: +60 11 3341 0688
Clinic Location:
NextMed Clinic Petaling Jaya
38, Jalan Gasing, Bukit Gasing, 46000 Petaling Jaya, Selangor
NextMed Clinic Cheras
8-G, Jalan Simfoni 1, Menara Simfoni, Cheras Selatan, Balakong, 43300 Seri Kembangan, Selangor
NextMed Clinic Setia Alam
71-G & 73-G Jalan Eco Ardence D U12/36D, 40170 Shah Alam, Selangor
Real Customer Review
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Read why customers chose NextMed Clinic.
Why Choose Us ?
As one of the Leading Aesthetic Clinic in Malaysia, NextMed Clinic provides top-notch procedures by Certified Medical Practitioners. Whatever your concerns, be it enhancing your natural features or reversing the signs of aging, NextMed Clinic is able to deliver a wide range of quality, state of art & personalized aesthetic, general health services & wellness solution, merged with exemplary service, in a warm and pleasent enviroment designed to make you feel completely at ease.
At NextMed Clinic, we strongly believe that each patient is unique. Therefore treatments are customized to each patient’s specific needs.

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